FHIR Implementation Guide Medication Process

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1 Introduction

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This is the FHIR implementation guide for the information standard Medicatieproces 9, version 2.0. This standard is described in this functional specification and implemented here using HL7 FHIR, R4. This implementation guide assumes that the reader is familiar with this FHIR version.

Apart from this document, the guidelines as specified in general FHIR Implementation Guide apply. In particular, the reader should take note of the Use case overarching principles and the use of FHIR packages.

Use cases:

2 Actors involved

Persons Systems FHIR Capability Statements
Name Description Name Description Name Description
Patient/Healthcare professional The user of a personal healthcare environment/XIS. Client A personal healthcare environment/healthcare information system Verwijzing.png CapabilityStatement: Client Client requirements
Healthcare professional The user of a XIS Server Healthcare information system Verwijzing.png CapabilityStatement: Server Server requirements

3 Use case: retrieve medication information

This FHIR implementation guide assumes that the PHR system is able to make a connection to the right XIS that contains the patient's information. It does not provide information on finding the right XIS nor does it provide information about security. Moreover, each transaction is performed in the context of a specific authenticated patient, for whose context (token) has been established using the authentication mechanisms described in the 'Afsprakenstelsel'. Each XIS Gateway is required to perform filtering based on the patient associated with the context for the request, so only the records associated with the authenticated patient are returned. For this reason, search parameters should not be included for patient identification.

3.1 Introduction

The retrieve medication information transaction is used by the client to retrieve medication information from the server. The client can retrieve the desired information by searching on specific medication building blocks.

3.2 Actors

Transaction group Transaction Actor Role
Retrieve Medication Information(PULL) Retrieve medication information request Client Request medication information
Retrieve medication information response Server Serves medication information

3.3 Invocations

3.3.1 Request message

When the patient or healthcare professional wants to obtain medication information matching various parameters, it issues a retrieve medication information request message. This message uses the HTTP GET method parameterized query to obtain medication information from a server. Multiple different HTTP GET request messages may be needed to retrieve all the desired medication information.

The client executes an HTTP GET against the server's medication FHIR endpoints. These endpoints can be one of the following:

  • MedicationRequest
  • MedicationDispense
  • MedicationStatement

The search interaction is performed by an HTTP GET conform the FHIR search specification, as shown below. This URL is configurable by the client by configuring the query search parameters and search control parameters to modify the behaviour of the server such as response format and pagination.

GET [base]/[type]{?[parameters]}

3.3.1.1 Query Search Parameters

The client may supply, and the server SHALL be capable of processing, all query parameters listed in the table below.

MP9 search parameters Description FHIR search parameter FHIR resource Example
Identification Search on identifier. identifier MedicationRequest, MedicationDispense, MedicationStatement Retrieves a MedicationRequest resource with the identifier 999922448.
GET [base]/MedicationRequest?identifier=http://example.nl/fhir/NamingSystem/MedicationRequest|999922448 
Type Search on type of medication building block (HCIM). category [1],[2] MedicationRequest Retrieves all MedicationRequest resources that represent a HCIM MedicationAgreement.
GET [base]/MedicationRequest?category=http://snomed.info/sct|16076005

Retrieves all MedicationRequest resources that represent a HCIM DispenseRequest.

GET [base]/MedicationRequest?category=http://snomed.info/sct|52711000146108
MedicationDispense Retrieves all MedicationDispense resources that represent a HCIM Dispense.
GET [base]/MedicationDispense?category=http://snomed.info/sct|373784005

Retrieves all MedicationRequest resources that represent a HCIM AdministrationAgreement.

GET [base]/MedicationRequest?category=http://snomed.info/sct|422037009
MedicationStatement Retrieves all MedicationStatement resources that represent a HCIM MedicationUse.
GET [base]/MedicationStatement?category=urn:oid:2.16.840.1.113883.2.4.3.11.60.20.77.5.3|6
ProductCode Search on medication code. code MedicationRequest, MedicationDispense, MedicationStatement, Medication Retrieves all MedicationRequest resources that represent a HCIM MedicationAgreement and have Carbasalaatcalcium Sandoz 600 30 as medication.
GET [base]/MedicationRequest?category=http://snomed.info/sct|16076005&medication.code=urn:oid:2.16.840.1.113883.2.4.4.8|13610554
UsePeriod Search on medication use in the past, present or future within the specified time period. periodofuse [2],[3] MedicationDispense, MedicationRequest Retrieves all MedicationRequest resources that represent a HCIM MedicationAgreement and were in effect from 01-01-2010.
GET [base]/MedicationRequest?category=http://snomed.info/sct|16076005&periodofuse=ge2010-01-01
DispensePeriod Returns all medication dispenses within the specific period. whenhandedover MedicationDispense Retrieves all MedicationDispense resources that represent a HCIM Dispense and were handed over within a 2 year period.
GET [base]/MedicationDispense?category=http://snomed.info/sct|373784005&whenhandedover=ge2010-01-01&whenhandedover=le2011-12-31
MedicationTreatment Search on the medication treatment identifier medicationtreatment [2] MedicationRequest, MedicationDispense, MedicationStatement Retrieves all MedicationRequest resources that are part of the medication treatment 1247848.
GET [base]/MedicationRequest?medicationtreatment=http://example.nl/fhir/NamingSystem/medicationtreatment|1247848 
- The client may request that the server returns resources related to the search results, in order to reduce the overall network delay of repeated retrievals of related resources. _include MedicationRequest, MedicationDispense, MedicationStatement Retrieves all MedicationRequest resources that have Carbasalaatcalcium Sandoz 600 30 as medication and includes the Medication resource in the search results.
GET [base]/MedicationRequest?medication.code=urn:oid:2.16.840.1.113883.2.4.4.8|13610554&_include=MedicationRequest:medication

3.3.1.2 Custom Search Parameters

The following custom search parameters are defined for this use case:

3.3.2 Response message

The server returns a HTTP Status code appropriate to the processing as well as a FHIR Bundle including the matching medication information.

The returned data to the client SHALL conform to the medication profiles. The table below lists the medication HCIMs and their respective FHIR profiles. The resources in the response message SHALL be a valid instance of these profiles. All resources SHALL include their related profile canonical URL in the meta.profile element in order to show compliance.

Note that the medication building blocks are grouped per 'medication treatment' conform to the Medication Process specification. Grouping SHALL be done by use of a 'medication treatment' identifier. This identifier shall be the same across different related medication resources that constitute a medication treatment. The zib-Medication-MedicationTreatment extension is added to all medication profiles and can be used for this grouping purpose.

3.4 List of Profiles

HCIM name NL HCIM name EN FHIR Resource FHIR Profile
Patient Patient Patient http://fhir.nl/fhir/StructureDefinition/nl-core-patient
Zorgverlener HealthProfessional Practitioner http://fhir.nl/fhir/StructureDefinition/nl-core-practitioner
Zorgaanbieder HealthcareProvider Organization http://fhir.nl/fhir/StructureDefinition/nl-core-organization
Medicatiegebruik MedicationUse MedicationStatement http://nictiz.nl/fhir/StructureDefinition/mp-MedicationUse
Toedieningsafspraak AdministrationAgreement MedicationDispense http://nictiz.nl/fhir/StructureDefinition/mp-AdministrationAgreement
Medicatieafspraak MedicationAgreement MedicationRequest http://nictiz.nl/fhir/StructureDefinition/mp-MedicationAgreement
Verstrekking Dispense MedicationDispense http://nictiz.nl/fhir/StructureDefinition/mp-Dispense
Verstrekkingsverzoek DispenseRequest MedicationRequest http://nictiz.nl/fhir/StructureDefinition/mp-DispenseRequest
Product Product Medication http://nictiz.nl/fhir/StructureDefinition/mp-Product
GebruiksInstructie InstructionsForUse Dosage (datatype) http://nictiz.nl/fhir/StructureDefinition/mp-InstructionsForUse

4 Use case: retrieve medication overview

This FHIR implementation guide assumes that the PHR system is able to make a connection to the right XIS that contains the patient's information. It does not provide information on finding the right XIS nor does it provide information about security. Moreover, each transaction is performed in the context of a specific authenticated patient, for whose context (token) has been established using the authentication mechanisms described in the 'Afsprakenstelsel'. Each XIS Gateway is required to perform filtering based on the patient associated with the context for the request, so only the records associated with the authenticated patient are returned. For this reason, search parameters should not be included for patient identification.

4.1 Introduction

The retrieve medication overview transaction is used by the client to retrieve a medication overview from the server.

4.2 Actors

Transaction group Transaction Actor Role
Retrieve Medication Overview(PULL) Retrieve medication overview request Client Request medication overview
Retrieve medication overview response Server Serves medication overview

4.3 Invocations

4.3.1 Request message

When the patient or healthcare professional wants to obtain the current medication overview, it issues a retrieve medication overview request message. This message uses an extended operation on the RESTful API to obtain a medication overview from a server. This operation is used because the server needs to play an active role in formulating the content of the response.

The client executes a medication-overview operation with HTTP POST against the server base endpoint as shown below.

POST [base]/$medication-overview


4.3.2 Response message

The server returns a HTTP Status code appropriate to the processing of the operation. The successful outcome of the $medication-overview operation is the body of the medication overview response message. Successful processing of this operation should result in a Bundle recourse of type 'searchset', containing one List and one Patient resource as entries along with all the resources that represent the current medication overview. These resources SHALL be referenced from the List resource. The clinical content of the medication overview is defined in the Medication Process specification. The functional dataset of the medication overview can be found on decor.nictiz.nl.

The content in the response message SHALL be a valid instance of the following profiles that are referenced in the medication-overview operation. Clicking on the link will open the formal definition on Simplifier.net.

The Bundle profile represents the structure of the retrieve medication overview response message. The List profile represents the actual medication overview. The List contains the medication overview metadata and references to all resources that constitute the medication overview. These resources are included in the Bundle as entries. The Bundle.total value contains the number of matching HCIMs: MedicationUse, AdministrationAgreement and MedicationAgreement. Other included resources, such as Medication resources, are not included in the total. The returned Bundle has at least one List and one Patient resource.

In the table below, the HCIMs that constitute the clinical content of the Medication Overview and their respective profiles are listed.

Note that the medication building blocks are grouped per 'medication treatment' conform the Medication Process specification. Grouping SHALL be done by use of a 'medication treatment' identifier. This identifier shall be the same across different related medication resources that constitute a medication treatment. The zib-Medication-MedicationTreatment extension is added to all medication profiles and can be used for this grouping purpose.

4.4 List of Profiles

HCIM name NL HCIM name EN FHIR Resource FHIR Profile
Patient Patient Patient http://fhir.nl/fhir/StructureDefinition/nl-core-patient
Zorgverlener HealthProfessional Practitioner http://fhir.nl/fhir/StructureDefinition/nl-core-practitioner
Zorgaanbieder HealthcareProvider Organization http://fhir.nl/fhir/StructureDefinition/nl-core-organization
Medicatiegebruik MedicationUse MedicationStatement http://nictiz.nl/fhir/StructureDefinition/mp-MedicationUse
Toedieningsafspraak AdministrationAgreement MedicationDispense http://nictiz.nl/fhir/StructureDefinition/mp-AdministrationAgreement
Medicatieafspraak MedicationAgreement MedicationRequest http://nictiz.nl/fhir/StructureDefinition/mp-MedicationAgreement
Product Product Medication http://nictiz.nl/fhir/StructureDefinition/mp-Product
GebruiksInstructie InstructionsForUse Dosage (datatype) http://nictiz.nl/fhir/StructureDefinition/mp-InstructionsForUse

5 Examples

  1. Medicatieproces has a wiki page that contains examples in FHIR and CDA for dosage instructions.
  2. Every profile or resource on Simplifier has a reference tab. The reference tab shows all references from and to the selected resource. So the listed profiles in these use cases have a reference tab on Simplifier where examples are listed that declare conformance to the specific profile.
  3. Examples are accessible through the Simplifier project by going to the resources tab of the project. It is possible to filter on examples and underlying FHIR resource. This is clarified with the following URL, which lists all medication examples available in the NictizSTU3-MedicationProcess project: https://simplifier.net/nictizstu3-medicationprocess/~resources?category=Example&exampletype=MedicationDispense%7CMedicationStatement%7CMedicationRequest%7CMedication&fhirVersion=STU3&sortBy=DisplayName

6 Release notes

Release notes can be found on the functional design page.

7 Footnotes

  1. The FHIR profiles that represent the medication building blocks contain fixed code values in the .category elements to allow searching on specific medication building blocks.
  2. 2,0 2,1 2,2 The search parameter consists of a custom FHIR search parameter not represented in the FHIR specification.
  3. 3,0 3,1 This SearchParameter searches on the FHIR DataType Period in the PeriodOfUse extension, which is added to profiles on MedicationRequest and MedicationDispense resources. Clients use date parameter searches as described by the FHIR specification. Servers are expected to take the MedicationUse-Duration extension into account when processing a client's search. This means that either a Period.start AND Period.end or Period.start AND Duration or Period.end AND Duration is used to determine the search results. To illustrate the expected behavior: if a Period.start and a Duration is known, but not the Period.end, the Duration should be added to the Period.start date to calculate the Period.end. The calculated Period.end date is then used to determine the search results.